anti-Heat Shock Factor 1 (HSF1) Ab-1, Clone: 4B4, Thermo Scientific™ Lab Vision™
The Thermo Scientific Heat Shock Factor 1 (HSF1) Ab-1, Rat Monoclonal Antibody provides accurate, reproducible results.
HSF1 responds to cellular stress signals such as heat, heavy metals, and oxidative reagents; binds to heat shock response elements (HSEs) in the upstream region of heat shock gene and activates their transcription. Some laboratories have reported that the constitutive, non-DNA binding, monomeric form of inactive HSF1 is located in the cytoplasm. Upon activation, HSF1 is trimerized and is localized in nucleus where it binds DNA.
|Antigen||Heat Shock Factor 1 (HSF1) Ab-1|
|Monoclonal or Polyclonal||Monoclonal|
|Primary or Secondary||Primary|
|Cross Reactivity||Human, Mouse, Rat|
|Immunogen||Recombinant mouse HSF1 protein (aa1-503)|
|Research Discipline||Stress Response|