anti-Heparan Sulfate Proteoglycan/Perlecan

 
638.94
(766.73 inc tax)
RT-794-PABX
In stock
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anti-Heparan Sulfate Proteoglycan/Perlecan, Clone: A7L6, Thermo Scientific™ Lab Vision

Rat Monoclonal Antibody

Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

AntigenHeparan Sulfate Proteoglycan/Perlecan Ab-1
Monoclonal or PolyclonalMonoclonal
Primary or SecondaryPrimary
Host SpeciesRat
CloneA7L6
IsotypeIgG2a
Cross ReactivityBovine, Human, Mouse, Porcine
Quantity200µL
FormatConcentrated
Concentration1mg/mL
ConjugateUnlabeled
ImmunogenMurine EHS laminin preparation
Regulatory StatusRUO
Research DisciplineAngiogenesis

Thermo Scientific
No.:RT-794-PABX

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